Symbol
Name
ID

Lrp1
low density lipoprotein receptor-related protein 1
MGI:96828

Phenotype annotations related to cardiovascular system

Darker colors indicate more annotations

Human Phenotypes	Erythema
Disease(s) Associated with LRP1	Erythema
keratosis pilaris atrophicans

Mouse Phenotypes

abnormal aorta tunica media morphology

abnormal aorta elastic tissue morphology

abnormal aorta smooth muscle morphology

abnormal ascending aorta morphology

dilated aorta bulb

dilated ascending aorta

abnormal coronary artery morphology

perivascular fibrosis

abnormal myocardial fiber morphology

atrioventricular septal defect

increased heart weight

enlarged heart

increased heart left ventricle size

dilated heart left ventricle

abnormal heart ventricle outflow tract morphology

cardiac interstitial fibrosis

dilated cardiomyopathy

hemorrhage

internal hemorrhage

decreased cardiac muscle contractility

abnormal heart echocardiography feature

aortic valve regurgitation

increased pulse pressure

decreased systemic arterial diastolic blood pressure

abnormal vascular smooth muscle physiology

decreased vasoconstriction

abnormal vascular wound healing

Availability

Mouse Genotype

Lrp1^b2b1554Clo/Lrp1^b2b1554Clo

Lrp1^{tm1.1(KOMP)Wtsi}/Lrp1^{tm1.1(KOMP)Wtsi}

Lrp1^tm1Her/Lrp1^tm1Her

Lrp1^{tm1.1(KOMP)Wtsi}/Lrp1⁺

Lrp1^tm2Her/Lrp1^tm2Her
Tg(Tagln-cre)1Her/0 (conditional)

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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